|
KMID : 1134820210500030211
|
|
Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 3 p.211 ~ p.218
|
|
|
Effect of Campbell Early Leaves Extract on Heart-Kidney Improvement Cardiomyopathy in Isoprenaline-Induced Rats
|
|
Hong Mi-Hyeon
Kim Hye-Yoom
|
|
|
Abstract
|
|
|
|
Many studies have shown that grapes have antioxidant, nerve protection, liver protection, and anti-cancer effects, but their effectiveness on leaves is not known. The study was conducted to identify the effectiveness of Campbell early leaves (CEL) in heart and kidney dysfunction. Cardiomyopathy was induced by a treatment with isoprenaline (ISO) in rats to confirm the improved effect of cardiac-kidney dysfunction (cardio-renal syndrome). ISO (10 mg/kg/d) was administered intraperitoneally for two weeks and was divided into five groups: CONT, control; ISO, isoprenaline 10 mg/kg/d; PRO, ISO+propranolol 10 mg/kg; CEL100, ISO+CEL 100 mg/kg/d; CEL200, ISO+CEL 200 mg/kg/d. The experiment was conducted for four weeks. As a result, the CEL groups showed an improvement in the value of the left ventricle mass index after exposure to ISO compared to the control group. Furthermore, the echocardiogram measurements showed that the CEL groups could recover the decrease in ejection fraction, fractional shortening, and stroke volume. To identify the heart-kidney functionality, albumin, osmotic, and blood nitrogen was measured in each group, which showed a significant increase in the ISO group, decreasing in the CEL group. The fibrosis of the kidneys also recovered in the CEL group. In conclusion, in cardiomyopathy caused by ISO-induced rats, CEL improves the heart and kidney function. Therefore, grape leaves and fruit are considered useful for improving the heart-kidney functional disorders in grape leaves.
|
|
|
KEYWORD
|
|
|
Campbell early leaves, cardiomyopathy, cardiorenal syndrome, heart-kidney dysfunction, functional food
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|